Pamene mafupa akupweteka, zimakhala ndi zotsatira zoipa pa moyo wa tsiku ndi tsiku wa nyama.
Nyamakazi ndi kutupa olowa matenda chifukwa cha matenda kapena immunological njira mu thupi. Mu agalu ndi amphaka, kuwonjezera pa kupunduka ndi kuyenda koletsedwa, kutentha kwakukulu ndi kutopa kumatha kuwonedwa nthawi zambiri. Ndi matenda olumikizana ndi bakiteriya, mafupa amakhala ofunda, otupa, komanso ofewa.
Ngati olowa kutupa chifukwa cha amkati, immunological njira, n'zofanana ndi nyamakazi nyamakazi mwa anthu. Ma immunocomplexes amapangidwa, omwe amaphwanyidwanso ndi chitetezo chamthupi, kutulutsa ma lysosomal enzymes osintha olowa. Rheumatoid factor, yomwe imatsimikiziridwa mumankhwala amunthu kuti iwonetsedwe, sizodalirika ngati njira zodziwira agalu.